Narang A.S., Mahato R.I. (Eds.) Targeted Delivery of Small and Macromolecular Drugs

CRC Press, 2010. — 629 p.Site-specific drug delivery and targeting is attracting much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Bringing together leading field experts, Targeted Delivery of Small and Macromolecular Drugs summarizes current progress with a focus on the novel ideas being explored to overcome these challenges. Focuses on the Targeted Drug Delivery Technologies that Utilize both Systemic and Local Routes of Administration. Leading experts discuss some of the most promising strategies for drug targeting. They also cover targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including:
Active targeting.
Nucleic acid delivery and targeting.
Intracellular/Organelle-Specific Strategies.
Prodrug Strategies.
Organ or Tissue-Specific drug delivery.
Drug-Polymer Conjugates and Micelles.
Stimuli-Responsive systems.
Targeted Delivery of Small and Macromolecular Drugs demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.EditorsTherapeutic Potential of Targeted Drug Delivery
Active Targeting
Antibody Therapies fo Liver Malignancy and Transplantation
Transferrin Receptor-Mediated Transcytosis in Intestinal Epithelial Cells for Gastrointestinal Absorption of Protein Drugs
Ionizing Radiation for Tumor-Targeted Drug Delivery
Nucleic Acid Delivery and Targeting
Recent Advances in Gene Expression and Delivery Systems
Cellular Barriers for Nucleic Acid Delivery and Targeting
Targeted Delivery Systems of Nonviral Nucleic Acid-Based Therapeutics
Delivery and Targeting of Oligonucleotides and siRNA
Liposomes for Nonviral Gene Delivery
Intracellular/Organelle-Specific Strategies
Delivering the Bullet to the Right Intracellular Target: A Cellular Perspective on Drug Delivery
Mitochondria-Targeted Drug Delivery
Prodrug Strategies
Site-Specific Prodrug Activation Strategies for Targeted Drug Action
Enzyme-Activated Prodrug Strategies for Targeted Drug Action
Organ- or Tissue-Specific Drug Delivery
Targeting Colon and Kidney: Pathophysiological Determinants of Design Strategy
Principles and Practice of Pulmonary Drug Delivery
Recent Advances in Ocular Drug Delivery: Role of Transporters, Receptors, and Nanocarriers
Polymer-Drug Conjugates and Micelles
Injectable Polymers for Regional Drug Delivery
Polymer-Drug Conjugates
Polymer Micelles for Drug Delivery
Stimuli-Responsive Systems
Multifunctional Stimuli-Responsive Nanoparticles for Targeted Delivery of Small and Macromolecular Therapeutics
Physiological Stress Responsive Gene Regulation Systems for Tissue Targeting