Parikh Dilip. How to Optimize Fluid Bed Processing Technology

Academic Press, 2017. — 210 p. — (Expertise in Pharmaceutical Process Technology). — ISBN: 9780128047279 ; ISBN: 9780128047286.How to Optimize Fluid Bed Processing Technology: Part of the Expertise in Pharmaceutical Process Technology Series addresses the important components of fluid bed granulation, providing answers to problems that commonly arise and using numerous practical examples and case studies as reference.
This book covers the theoretical concepts involved in fluidization, also providing a description of the choice and functionality of equipment. Additional chapters feature key aspects of the technology, including formulation requirements, process variables, process scale-up, troubleshooting, new development, safety, and process evaluation.Key FeaturesWritten by an expert in the field with several years of experience in product development, manufacturing, plant operations, and process engineering
Illustrates when fluid bed granulation is needed, when to use less common fluid bed granulation methods, and the advantages of fluid bed granulation when compared to other granulation techniques
Offers troubleshooting tips and practical advice for scientists working with this techniqueReadership
Pharmaceutical personnel, from R&D technicians to team leaders and department headsAbstractAdvantages and Challenges of Fluidized Bed Granulation
Fluidization Theory
Abstract
How Does Fluidization Take Place?
Understanding the Particles
Types of Fluid Beds
Controlling Gas Velocity
Addressing Fluidization ChallengesFluid Bed Processor Equipment and Its Functionality
AbstractQuestions Before Specifying the Equipment
Fluid Bed Processor ComponentsProcess Development
Abstract
Process Selection
Quality by Design
Processing in Fluid Bed
Risk Assessment and Management
Process Control
Case StudyGranulation
Abstract
Theory
Binders
Nozzles
Process Parameters
Challenges in Fluid Bed Granulation
Granulation End Point
Granulation CharacterizationDrying
Abstract
Theory
Drying Granulated ProductCoating
AbstractTop-Spray Coating
Wurster Coating
Other Coating Modules
Dry Powder Coating
Problems in Coating in Fluid Bed
Characterization of the Coating
Selection of the Process for CoatingPelletization
AbstractPelletization With Wurster Coating Module
Pelletization in Rotary Fluid Bed
Case Studies
Characterization of PelletsOther Fluid Bed Processes and Applications
AbstractFluidized Hot Melt Granulation (FHMG)
Spray Congealing
Pressure Swing Granulation (PSG)
Wurster Module for Granulation
Foam Granulation
Steam Granulation
Rotary Fluid Bed Agglomeration
Spray-Drying Granulation
Continuous GranulationProcess Control and PAT
Abstract
Background
Process Control
Temperature Measurement
NIR
Chord Length Determination (FBRM and SFV)
The Lighthouse Probe
Image analysis
Other methodsProcess Scale-Up
AbstractVarious Scale-Up Considerations and Approaches
Scale-Up of Fluid Bed Granulation and Drying
Case Studies—Granulation Scale-Up
Fluid Bed Coating Scale-Up
Rotary Fluid Bed CoatingIntegrated Systems
Abstract
Material Handling
Integrated Systems for Nonpotent Compounds
Integrated Systems for Potent CompoundsProcess Troubleshooting
Abstract
Troubleshooting the Granulation Process
Troubleshooting the Drying Process
Troubleshooting the Coating ProcessFluid Bed Safety
AbstractSafety From Solvents